Most sacks in an NFL game
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Derrick Thomas leads with 7 sacks on Nov 11, 1990 vs SEA, first of 46,188 games.
| # | Player and seasons | Value |
|---|---|---|
Derrick ThomasNov 11, 1990 ·  KC vs  SEA | 7 | |
Fred DeanNov 13, 1983 ·  SF vs  NO | 6 | |
Derrick ThomasSep 6, 1998 · KC vs  LV | 6 | |
Osi UmenyioraSep 30, 2007 ·  NYG vs  PHI | 6 | |
Adrian ClaybornNov 12, 2017 ·  ATL vs  DAL | 6 | |
Khalil MackOct 1, 2023 ·  LAC vs LV | 6 | |
William GaySep 4, 1983 ·  DET @  TB | 5.5 | |
Aldon SmithNov 19, 2012 · SF vs  CHI | 5.5 | |
Howie LongOct 2, 1983 · LV @  WAS | 5 | |
Randy HollowaySep 16, 1984 ·  MIN vs ATL | 5 | |
| Jim JeffcoatNov 10, 1985 · DAL @ WAS | 5 | |
| Leslie O'NealNov 16, 1986 · LAC vs DAL | 5 | |
Gary JeterSep 18, 1988 ·  LA @ LV | 5 | |
| Chuck SmithOct 12, 1997 · ATL @ NO | 5 | |
Vonnie HollidayDec 22, 2002 ·  GB vs  BUF | 5 | |
Antwan OdomSep 20, 2009 ·  CIN @ GB | 5 | |
Khalil MackDec 13, 2015 · LV @  DEN | 5 | |
Haason ReddickDec 13, 2020 ·  ARI @ NYG | 5 | |
Chandler JonesSep 12, 2021 · ARI @  TEN | 5 | |
Myles GarrettOct 26, 2025 ·  CLE @  NE | 5 | |
| Curtis GreerDec 18, 1983 · ARI vs PHI | 4.5 | |
| Richard DentNov 4, 1984 · CHI vs LV | 4.5 | |
Johnie CooksNov 25, 1984 ·  IND @ LV | 4.5 | |
| Richard DentDec 27, 1987 · CHI @ LV | 4.5 | |
| Kevin GreeneDec 18, 1988 · LA @ SF | 4.5 |