Most rushing yards in an NFL game since 1966

players with the most rushing yards in a game, regular season, since 1966, any team. reset

Adrian Peterson leads with 296 rushing yards on Nov 4, 2007 vs LAC, first of 103,098 games since 1966.

Most rushing yards in an NFL game since 1966

#	Player and seasons	Value
1	Adrian PetersonNov 4, 2007 · MIN vs LAC	296
2	Jamal LewisSep 14, 2003 · BAL vs CLE	295
3	Jerome HarrisonDec 20, 2009 · CLE @ KC	286
4	Corey DillonOct 22, 2000 · CIN vs DEN	278
5	Walter PaytonNov 20, 1977 · CHI vs MIN	275
6	O.J. SimpsonNov 25, 1976 · BUF @ DET	273
7	Shaun AlexanderNov 11, 2001 · SEA vs LV	266
8	Jamaal CharlesJan 3, 2010 · KC @ DEN	259
9	Saquon BarkleyNov 24, 2024 · PHI @ LA	255
T10	DeMarco MurrayOct 23, 2011 · DAL vs LA	253
T10	Jonathan TaylorJan 3, 2021 · IND vs JAX	253
T12	Mike AndersonDec 3, 2000 · DEN @ NO	251
T12	Doug MartinNov 4, 2012 · TB @ LV	251
T14	O.J. SimpsonSep 16, 1973 · BUF @ NE	250
T14	Derrick HenryJan 3, 2021 · TEN @ HOU	250
16	Willie EllisonDec 5, 1971 · LA vs NO	247
17	Corey DillonDec 4, 1997 · CIN vs TEN	246
18	Jonathan TaylorNov 9, 2025 · IND @ ATL	244
19	LaDainian TomlinsonDec 28, 2003 · LAC vs LV	243
20	Derrick HenryDec 6, 2018 · TEN vs JAX	238
T21	Emmitt SmithOct 31, 1993 · DAL @ PHI	237
T21	Barry SandersNov 13, 1994 · DET vs TB	237
23	Le'Veon BellDec 11, 2016 · PIT @ BUF	236
24	Doug MartinNov 22, 2015 · TB @ PHI	235
T25	Fred TaylorNov 19, 2000 · JAX @ PIT	234