| Terrell Davis (1998 DEN)1998 | 1,150 |
| O.J. Simpson (1975 BUF)1975 | 1,128 |
| O.J. Simpson (1973 BUF)1973 | 1,104 |
| Terrell Davis (1997 DEN)1997 | 1,068 |
| DeMarco Murray (2014 DAL)2014 | 1,054 |
| Jamal Lewis (2003 BAL)2003 | 1,045 |
| Adrian Peterson (2007 MIN)2007 | 1,036 |
| Barry Sanders (1994 DET)1994 | 1,035 |
| Eric Dickerson (1986 LA)1986 | 1,030 |
| Eric Dickerson (1983 LA)1983 | 995 |
| Stephen Davis (2003 CAR)2003 | 992 |
| Emmitt Smith (1995 DAL)1995 | 979 |
| Earl Campbell (1980 TEN)1980 | 964 |
| Chris Johnson (2009 TEN)2009 | 959 |
| Dalvin Cook (2020 MIN)2020 | 954 |
| Shaun Alexander (2005 SEA)2005 | 949 |
| Walter Payton (1984 CHI)1984 | 947 |
| Derrick Henry (2024 BAL)2024 | 946 |
| Freeman McNeil (1985 NYJ)1985 | 945 |
| Clinton Portis (2008 WAS)2008 | 944 |
| Derrick Henry (2021 TEN)2021 | 937 |
| Walter Payton (1977 CHI)1977 | 937 |
| Eric Dickerson (1984 LA)1984 | 925 |
| Saquon Barkley (2024 PHI)2024 | 925 |
| Edgerrin James (2000 IND)2000 | 921 |