| Eric Dickerson (1984 LA)1984 | 2,105 |
| Adrian Peterson (2012 MIN)2012 | 2,097 |
| Jamal Lewis (2003 BAL)2003 | 2,063 |
| Barry Sanders (1997 DET)1997 | 2,053 |
| Derrick Henry (2020 TEN)2020 | 2,027 |
| Terrell Davis (1998 DEN)1998 | 2,008 |
| Chris Johnson (2009 TEN)2009 | 2,006 |
| Saquon Barkley (2024 PHI)2024 | 2,005 |
| O.J. Simpson (1973 BUF)1973 | 2,003 |
| Earl Campbell (1980 TEN)1980 | 1,934 |
| Derrick Henry (2024 BAL)2024 | 1,921 |
| Barry Sanders (1994 DET)1994 | 1,883 |
| Ahman Green (2003 GB)2003 | 1,883 |
| Shaun Alexander (2005 SEA)2005 | 1,880 |
| Tiki Barber (2005 NYG)2005 | 1,860 |
| Ricky Williams (2002 MIA)2002 | 1,853 |
| Walter Payton (1977 CHI)1977 | 1,852 |
| Jamal Anderson (1998 ATL)1998 | 1,846 |
| DeMarco Murray (2014 DAL)2014 | 1,845 |
| Eric Dickerson (1986 LA)1986 | 1,821 |
| O.J. Simpson (1975 BUF)1975 | 1,817 |
| LaDainian Tomlinson (2006 LAC)2006 | 1,815 |
| Jonathan Taylor (2021 IND)2021 | 1,811 |
| Eric Dickerson (1983 LA)1983 | 1,808 |
| Larry Johnson (2006 KC)2006 | 1,789 |