| Lionel Messi (2019-20 Barcelona)2019-20 | 21 |
| Xavi (2008-09 Barcelona)2008-09 | 20 |
| Lionel Messi (2010-11 Barcelona)2010-11 | 18 |
| Lionel Messi (2014-15 Barcelona)2014-15 | 18 |
| Gutí (2007-08 Real Madrid)2007-08 | 17 |
| Mesut Özil (2010-11 Real Madrid)2010-11 | 17 |
| Ángel Di María (2013-14 Real Madrid)2013-14 | 17 |
| Andrés Iniesta (2012-13 Barcelona)2012-13 | 16 |
| Cristiano Ronaldo (2014-15 Real Madrid)2014-15 | 16 |
| Lionel Messi (2015-16 Barcelona)2015-16 | 16 |
| Luis Suárez (2015-16 Barcelona)2015-16 | 16 |
| Antoine Griezmann (2022-23 Atlético Madrid)2022-23 | 16 |
| Ariel Ibagaza (2007-08 Mallorca)2007-08 | 15 |
| Dani Alves (2010-11 Barcelona)2010-11 | 15 |
| Ángel Di María (2011-12 Real Madrid)2011-12 | 15 |
| Lionel Messi (2011-12 Barcelona)2011-12 | 15 |
| Dani Alves (2007-08 Sevilla)2007-08 | 14 |
| Xavi (2009-10 Barcelona)2009-10 | 14 |
| Luis Suárez (2014-15 Barcelona)2014-15 | 14 |
| Koke (2015-16 Atlético Madrid)2015-16 | 14 |
| Álex Baena (2023-24 Villarreal)2023-24 | 14 |
| Ronaldinho (2005-06 Barcelona)2005-06 | 13 |
| Juan Mata (2008-09 Valencia)2008-09 | 13 |
| Xabi Prieto (2010-11 Real Sociedad)2010-11 | 13 |
| Mesut Özil (2011-12 Real Madrid)2011-121 of his appearances has no assists recorded, so the number is short. | 13 |