| Jonathan Taylor2017 – 2019inactive after 41 games | 6,174 |
| Donnel Pumphrey2013 – 2016 | 6,051 |
| Royce Freeman2014 – 2017 | 5,499 |
| Damion Fletcher2006 – 2009 | 5,302 |
| Justin Jackson2014 – 2017 | 5,283 |
|  Montel Harris2008 – 2012 | 5,140 |
| Montee Ball2009 – 2012inactive after 49 games | 5,140 |
| Myles Gaskin2015 – 2018 | 5,131 |
| LaMike James2009 – 2011inactive after 37 games | 5,082 |
| Mike Hart2004 – 2007inactive after 43 games | 5,040 |
| Kareem Hunt2013 – 2016inactive after 43 games | 4,945 |
| Ray Rice2005 – 2007inactive after 38 games | 4,926 |
| Melvin Gordon III2011 – 2014inactive after 43 games | 4,915 |
| Ashton Jeanty2022 – 2024inactive after 40 games | 4,769 |
| Nick Chubb2014 – 2017inactive after 47 games | 4,769 |
|   Marquez Cooper2020 – 2024 | 4,703 |
| Jarvion Franklin2014 – 2017 | 4,700 |
| Travis Etienne Jr.2017 – 2020 | 4,644 |
| Ito Smith2014 – 2017 | 4,444 |
|  Xazavian Valladay2018 – 2022 | 4,376 |
| Ameer Abdullah2011 – 2014 | 4,296 |
| Noel Devine2007 – 2010 | 4,264 |
| Elijah McGuire2013 – 2016 | 4,208 |
| Zach Line2009 – 2012 | 4,185 |
| Stepfan Taylor2009 – 2012 | 4,134 |
| Johnathan Franklin2009 – 2012 | 4,110 |
| Tahj Brooks2020 – 2024 | 4,099 |
| Charles Williams2016 – 2021 | 4,064 |
| Colin Kaepernick2007 – 2010 | 4,040 |
| Rodney Smith2015 – 2019 | 4,022 |
| James White2010 – 2013 | 3,852 |
| A.J. Ouellette2014 – 2018 | 3,829 |
| Najee Harris2017 – 2020 | 3,764 |
|   Harrison Waylee2020 – 202549 of 50 games | 3,755 |
| Tim Cornett2010 – 2013 | 3,733 |