| Keenan Reynolds2012 – 2015inactive after 49 games | 88 |
| Montee Ball2009 – 2012inactive after 49 games | 77 |
| Kenneth Dixon2012 – 2015inactive after 47 games | 72 |
| Devin Singletary2016 – 2018inactive after 38 games | 66 |
| Travis Etienne Jr.2017 – 2020 | 65 |
| Colin Kaepernick2007 – 2010 | 59 |
| Donnel Pumphrey2013 – 2016 | 59 |
| Royce Freeman2014 – 2017 | 58 |
| Blake Corum2020 – 2023inactive after 45 games | 58 |
| Ian Johnson2005 – 2008inactive after 49 games | 58 |
| Collin Klein2009 – 2012inactive after 41 games | 56 |
| Myles Gaskin2015 – 2018 | 55 |
| LaMike James2009 – 2011inactive after 37 games | 53 |
| Mohamed Ibrahim2018 – 2022inactive after 40 games | 53 |
| Tim Tebow2006 – 2009 | 52 |
| Jarvion Franklin2014 – 2017 | 51 |
| Kory Sheets2005 – 2008 | 48 |
| Zach Line2009 – 2012 | 47 |
| Dan LeFevour2006 – 2009 | 46 |
|  Montel Harris2008 – 2012 | 46 |
| James White2010 – 2013 | 45 |
| Xavier Jones2015 – 2019 | 45 |
| Damion Fletcher2006 – 2009 | 44 |
| Malik Cunningham2018 – 2022 | 44 |
| Najee Harris2017 – 2020 | 44 |
| J.T. Barrett2014 – 2017 | 43 |
| Elijah McGuire2013 – 2016 | 42 |
| Ito Smith2014 – 2017 | 42 |
|   Marquez Cooper2020 – 2024 | 42 |
| Nicholas Singleton2022 – 2025 | 41 |
| SaRodorick Thompson Jr.2018 – 2022 | 40 |
|  CJ Donaldson2022 – 202545 of 50 games | 40 |
| Justin Jackson2014 – 2017 | 39 |
| Ronnie Rivers2017 – 2021 | 39 |
| Stepfan Taylor2009 – 2012 | 38 |