| Case Keenum2007 – 2011 | 32 |
| Graham Harrell2005 – 2008inactive after 44 games | 32 |
| Luke Falk2014 – 2017inactive after 42 games | 30 |
| Landry Jones2009 – 2012 | 27 |
|  Dillon Gabriel2019 – 2023 | 23 |
|  Will Rogers2020 – 2024 | 23 |
| Seth Henigan2021 – 2024 | 22 |
| Brett Rypien2015 – 2018 | 21 |
|  Sam Hartman2018 – 2023 | 21 |
| Chase Daniel2005 – 2008 | 20 |
| Holton Ahlers2018 – 2022 | 16 |
| Kenny Pickett2017 – 2021 | 16 |
|  Josh Hoover2022 – 202643 of 50 games | 16 |
| Kellen Moore2008 – 2011 | 15 |
| Rakeem Cato2011 – 2014 | 15 |
| Colt McCoy2006 – 2009 | 14 |
| Drew Lock2015 – 2018 | 14 |
|  Russell Wilson2008 – 2011 | 14 |
|  Caden Veltkamp2022 – 202636 of 50 games | 14 |
|  Brennan Armstrong2018 – 2023 | 13 |
| Cooper Rush2013 – 2016 | 13 |
| Dan LeFevour2006 – 2009 | 13 |
|   Darian Mensah2024 – 202635 of 50 games | 13 |
|  Drew Mestemaker2024 – 202626 of 50 games | 13 |
| Noah Fifita2022 – 202648 of 50 games | 13 |
|   Charlie Brewer2017 – 2022 | 12 |
| Frank Harris2019 – 2023 | 12 |
|  Jayden Daniels2019 – 2023 | 12 |
|   Layne Hatcher2019 – 2023 | 12 |
|  Carson Beck2021 – 2025 | 11 |
| Gunnar Watson2018 – 2023 | 11 |
|    Chandler Morris2020 – 202545 of 50 games | 11 |
| Kevin Jennings2022 – 202646 of 50 games | 11 |
|  Sawyer Robertson2022 – 202533 of 50 games | 11 |
| Aaron Murray2010 – 2013 | 10 |