| Jonathan Taylor2017 – 2019inactive after 41 games | 32 |
| Donnel Pumphrey2013 – 2016 | 31 |
| Royce Freeman2014 – 2017 | 30 |
|  Montel Harris2008 – 2012 | 28 |
| Kareem Hunt2013 – 2016inactive after 43 games | 28 |
| Mike Hart2004 – 2007inactive after 43 games | 28 |
| Justin Jackson2014 – 2017 | 26 |
| LaMike James2009 – 2011inactive after 37 games | 26 |
| Montee Ball2009 – 2012inactive after 49 games | 26 |
| Vai Taua2007 – 2010inactive after 41 games | 26 |
| Damion Fletcher2006 – 2009 | 25 |
| Myles Gaskin2015 – 2018 | 25 |
| Ray Rice2005 – 2007inactive after 38 games | 25 |
| Mohamed Ibrahim2018 – 2022inactive after 40 games | 24 |
| Nick Chubb2014 – 2017inactive after 47 games | 24 |
| Ameer Abdullah2011 – 2014 | 23 |
| Ito Smith2014 – 2017 | 23 |
| Jarvion Franklin2014 – 2017 | 21 |
| Stepfan Taylor2009 – 2012 | 21 |
|  Xazavian Valladay2018 – 2022 | 21 |
|   Marquez Cooper2020 – 2024 | 20 |
| Tahj Brooks2020 – 2024 | 20 |
| Zach Line2009 – 2012 | 20 |
| Noel Devine2007 – 2010 | 19 |
| Travis Etienne Jr.2017 – 2020 | 19 |
| Johnathan Franklin2009 – 2012 | 18 |
| Elijah McGuire2013 – 2016 | 17 |
| James White2010 – 2013 | 17 |
| Colin Kaepernick2007 – 2010 | 16 |
|  Nate Noel2020 – 2024 | 16 |
| Rodney Smith2015 – 2019 | 16 |
| Tarrion Adams2005 – 2008 | 16 |
| Tim Cornett2010 – 2013 | 16 |
|  Ahmad Hardy2024 – 202626 of 50 games | 16 |
| Rashaad Penny2014 – 2017 | 15 |