Most sacks in a career with the Bills
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Bruce Smith leads with 171 sacks with the Bills, first of the 499 who played with the Bills. Greg Rousseau is 8th, with 39 sacks with the Bills. 5 more sacks passes Mario Williams for 7th.
171game 1217
- Bruce Smith
- Aaron Schobel
- Phil Hansen
| # | Player and seasons | Value |
|---|---|---|
| Bruce Smith1985 – 1999 | 171 | |
| Aaron Schobel2001 – 2009 | 79 | |
| Phil Hansen1991 – 2001 | 61.5 | |
| Jerry Hughes2013 – 2021 | 53 | |
| Cornelius Bennett1987 – 1995 | 52.5 | |
| Kyle Williams2006 – 2018 | 49.5 | |
| Mario Williams2012 – 2015 | 43 | |
| Greg Rousseau2021 – 2026 | 39 | |
| Darryl Talley1983 – 1994 | 38.5 | |
| Marcell Dareus2011 – 2017 | 35 | |
| Bryce Paup1995 – 1997 | 33 | |
| Chris Kelsay2003 – 2012 | 33 | |
| Jeff Wright1988 – 1994 | 31.5 | |
| Ed Oliver2019 – 2026 | 30.5 | |
| Lorenzo Alexander2016 – 2019 | 24 | |
| A.J. Epenesa2020 – 2025 | 24 | |
| Ryan Denney2002 – 2009 | 22 | |
| Sam Rogers1994 – 2000 | 21.5 | |
| Shaq Lawson2016 – 2023 | 21 | |
| Marcellus Wiley1997 – 2000 | 19 | |
| Fred Smerlas1979 – 1989 | 18.5 | |
| Ben Williams1976 – 1985 | 17.5 | |
| Sean McNanie1984 – 1987 | 15 | |
| Leon Seals1987 – 1991 | 14.5 | |
| London Fletcher2002 – 2006 | 14.5 |