| LaMike James2009 – 2010 | 3,277 |
| Royce Freeman2014 – 2015 | 2,757 |
| Bucky Irving2022 – 2023 | 2,098 |
| CJ Verdell2018 – 2019 | 1,981 |
| Byron Marshall2012 – 2014 | 1,664 |
| Jonathan Stewart2005 – 2007 | 1,492 |
| Jeremiah Masoli2008 – 2009inactive after 24 games | 1,386 |
| Travis Dye2018 – 2019 | 1,381 |
| Marcus Mariota2012 – 2013 | 1,334 |
| Thomas Tyner2013 – 2014inactive after 23 games | 1,284 |
| Tony Brooks-James2015 – 2017 | 1,271 |
| Jeremiah Johnson2005 – 2008 | 1,240 |
| Noah Whittington2022 – 2024 | 1,233 |
| De'Anthony Thomas2011 – 2012 | 1,159 |
| Jordan James2022 – 2024 | 1,145 |
| Jordon Davison2025 – 202622 of 25 games | 1,106 |
| LeGarrette Blount2008 – 2009inactive after 16 games | 1,084 |
| Dierre Hill Jr.2025 – 202623 of 25 games | 1,055 |
| Kenjon Barner2009 – 2011 | 924 |
| Taj Griffin2015 – 2017 | 848 |
| Kani Benoit2014 – 2016 | 762 |
| Anthony Brown Jr.2020 – 2021inactive after 16 games | 698 |
| Remene Alston Jr.2007 – 2010inactive after 21 games | 692 |
| Bo Nix2022 – 2023 | 669 |
| Andre Crenshaw2006 – 2009 | 663 |
| Darron Thomas2008 – 2011 | 617 |
| Ayele Forde2011 – 2014inactive after 23 games | 555 |
| Dennis Dixon2004 – 2006 | 497 |
| Justin Herbert2016 – 2018 | 494 |
| Byron Cardwell Jr.2021 – 2022inactive after 13 games | 493 |
| Jayden Limar2023 – 2025 | 442 |
| Cyrus Habibi-Likio2018 – 2020 | 409 |
| Da'Jaun Riggs2024 – 202610 of 25 games | 241 |
| Josh Huff2010 – 2012 | 214 |
| Charles Nelson2014 – 2015 | 210 |