| Leonard Fournette2014 – 2015 | 2,987 |
| Jeremy Hill2012 – 2013inactive after 22 games | 2,156 |
| Derrius Guice2015 – 2017 | 2,047 |
| Jayden Daniels2022 – 2023 | 1,899 |
| Stevan Ridley2008 – 2010inactive after 22 games | 1,419 |
| Caden Durham2024 – 2026 | 1,261 |
| Charles Scott2006 – 2008 | 1,171 |
| Alfred Blue2010 – 2013 | 1,124 |
| Nick Brossette2015 – 2018 | 1,098 |
| Michael Ford2010 – 2012 | 1,074 |
| Spencer Ware2010 – 2012 | 1,010 |
| Keiland Williams2006 – 2008 | 955 |
| Terrence Magee2011 – 2014 | 903 |
| Clyde Edwards-Helaire2017 – 2019 | 821 |
| Kenny Hilliard2011 – 2013 | 808 |
| Tyrion Davis-Price2019 – 2021 | 808 |
| Josh Williams2020 – 2023 | 772 |
| Darrel Williams2014 – 2016 | 751 |
| John Emery Jr.2019 – 2022 | 746 |
| Harlem Berry2025 – 202621 of 25 games | 693 |
| Dilin Jones20268 of 25 games | 659 |
| Logan Diggs2023inactive after 10 games | 653 |
| Joe Burrow2018 – 2019 | 647 |
| Noah Cain2022 – 2023inactive after 21 games | 590 |
| Trindon Holliday2006 – 2008 | 550 |
| Jordan Jefferson2008 – 2010 | 536 |
| Jacob Hester2004 – 2006 | 528 |
| Russell Shepard2009 – 2011 | 519 |
| Richard Murphy2007 – 2009 | 419 |
| Brandon Harris2014 – 2016inactive after 22 games | 370 |
| Chris Curry2018 – 2020inactive after 18 games | 336 |
| Armoni Goodwin2021 – 2022inactive after 13 games | 332 |
| Kaleb Jackson2023 – 2025 | 331 |
| Sam Leavitt20268 of 25 games | 324 |
| Matt Flynn2004 – 2007 | 282 |