| T.J. Yeldon2012 – 2013 | 2,271 |
| Mark Ingram II2008 – 2009 | 2,127 |
| Derrick Henry2013 – 2015 | 1,615 |
| Jalen Hurts2016 – 2017 | 1,610 |
| Eddie Lacy2010 – 2012 | 1,571 |
| Trent Richardson2009 – 2010 | 1,451 |
| Bo Scarbrough2015 – 2017 | 1,293 |
| Jase McClellan2020 – 2023 | 1,249 |
| Glen Coffee2005 – 2008 | 1,214 |
| Damien Harris2015 – 2016 | 1,194 |
| Terry Grant2006 – 2009 | 1,167 |
| Najee Harris2017 – 2018 | 1,153 |
| Kenyan Drake2012 – 2014 | 1,087 |
| Jahmyr Gibbs2022inactive after 12 games | 926 |
| Brian Robinson Jr.2017 – 2019 | 863 |
| Jalen Milroe2021 – 2023 | 851 |
| Josh Jacobs2016 – 2017 | 851 |
| Jam Miller2022 – 2024 | 826 |
| Roy Upchurch2006 – 2009 | 768 |
| Jalston Fowler2010 – 2013 | 669 |
| Daniel Hill2024 – 2026 | 641 |
| Justice Haynes2023 – 2024inactive after 18 games | 616 |
| Roydell Williams2020 – 2022 | 605 |
| Jimmy Johns2005 – 2007inactive after 23 games | 564 |
| Trey Sanders2020 – 2022inactive after 20 games | 528 |
| Blake Sims2011 – 2014 | 504 |
| Tua Tagovailoa2017 – 2019 | 371 |
| Trae'shawn Brown20268 of 25 games | 324 |
| Kevin Riley2024 – 202617 of 25 games | 309 |
| Keelon Russell2025 – 202610 of 25 games | 268 |
| Richard Young2023 – 202514 of 25 games | 234 |
| Ty Simpson2022 – 2025 | 225 |
| EJ Crowell20267 of 25 games | 216 |
| AK Dear2025 – 20267 of 25 games | 146 |
| Germie Bernard2024 – 2025 | 138 |