| Connor HallidayOct 4, 2014 · Washington State vs California | 734 |
| Patrick MahomesOct 22, 2016 · Texas Tech vs Oklahoma | 734 |
| Geno SmithSep 29, 2012 · West Virginia vs Baylor | 656 |
| Graham HarrellSep 22, 2007 · Texas Tech @ Oklahoma State | 646 |
| Cody HodgesOct 15, 2005 · Texas Tech vs Kansas State | 643 |
| KJ CostelloSep 26, 2020 · Mississippi State @ LSU | 623 |
| Drew MestemakerOct 24, 2025 · North Texas @ Charlotte | 608 |
| Anthony GordonNov 23, 2019 · Washington State vs Oregon State | 606 |
| Alan BowmanSep 15, 2018 · Texas Tech vs Houston | 605 |
| Daniel MeagerSep 8, 2007 · North Texas @ SMU | 601 |
| Luke FalkNov 22, 2014 · Washington State @ Arizona State | 601 |
| Dillon GabrielOct 17, 2020 · UCF @ Memphis | 601 |
| Patrick MahomesNov 29, 2014 · Texas Tech @ Baylor | 598 |
| Baker MayfieldNov 4, 2017 · Oklahoma @ Oklahoma State | 598 |
| Drew AndersonOct 7, 2017 · Buffalo vs Western Michigan | 597 |
| Brandon DoughtySep 13, 2014 · Western Kentucky @ Middle Tennessee | 593 |
| Nick MullensOct 1, 2016 · Southern Miss vs Rice | 591 |
| Blake FrohnapfelSep 27, 2014 · UMass vs Bowling Green | 589 |
| Patrick MahomesNov 25, 2016 · Texas Tech @ Baylor | 586 |
| Nick FlorenceSep 29, 2012 · Baylor @ West Virginia | 581 |
| David PilandSep 8, 2012 · Houston vs Louisiana Tech | 580 |
| Deshaun WatsonNov 12, 2016 · Clemson vs Pittsburgh | 580 |
| Kyle VantreaseOct 15, 2022 · Georgia Southern vs James Madison | 578 |
| Bailey ZappeDec 3, 2021 · Western Kentucky @ UTSA | 577 |
| C.J. StroudJan 1, 2022 · Ohio State @ Utah | 573 |